Reduction of chronic hypoxic pulmonary hypertension in the rat by beta-aminopropionitrile.

Published

Journal Article

We administered antifibrotic agent beta-aminopropionitrile (BAPN) to rats exposed to 10% O2-90% N2 for 3 wk to prevent excess vascular collagen accumulation. Groups of Sprague-Dawley rats studied were air breathing, hypoxic, and hypoxic treated with BAPN, 150 mg/kg twice daily intraperitoneally. After the 3-wk period, we measured mean right ventricular pressure (RVP), the ratio of weight of right ventricle to left ventricle plus septum (RV/LV + S), and hydroxyproline content of the main pulmonary artery (PA) trunk. Hypoxia increased RVP from 14 to 29 mmHg; RVP was 21 mmHg in hypoxic BAPN-treated animals. Hypoxia increased the RV/LV + S ratio from 0.28 to 0.41; the ratio was 0.32 in hypoxic BAPN-treated animals. Hypoxia increased PA hydroxyproline from 20 to 239 micrograms/artery; hydroxyproline was 179 micrograms/artery in hypoxic BAPN-treated animals. Thus BAPN prevented pulmonary hypertension, right ventricular hypertrophy, and excess vascular collagen produced by hypoxia. We conclude that vascular collagen contributes to the maintenance of chronic hypoxic pulmonary hypertension.

Full Text

Duke Authors

Cited Authors

  • Kerr, JS; Riley, DJ; Frank, MM; Trelstad, RL; Frankel, HM

Published Date

  • December 1984

Published In

Volume / Issue

  • 57 / 6

Start / End Page

  • 1760 - 1766

PubMed ID

  • 6511550

Pubmed Central ID

  • 6511550

International Standard Serial Number (ISSN)

  • 0161-7567

Digital Object Identifier (DOI)

  • 10.1152/jappl.1984.57.6.1760

Language

  • eng

Conference Location

  • United States