Linkage between brain blood flow and respiratory drive during rapid-eye-movement sleep.


Journal Article

The correlation between brain blood flow (BBF) and respiratory neuromotor output, as reflected by diaphragmatic electromyogram (EMG) activity (EMGdi), was studied during wakefulness, rapid-eye-movement (REM) sleep, and non-REM sleep (NREM). Compared with the awake state, mean BBF increased by 4.7% during NREM and by 32.6% during REM (P less than 0.001). Also, surges of BBF during REM occurred during periods of intense phasic activity. EMGdi [peak and peak/inspiratory time (TI)] was highly variable within REM periods but fluctuated as a reciprocal function of simultaneously measured BBf (r = -0.49, P less than 0.001). Furthermore, mean EMGdipeak decreased from NREM to REM in a manner reciprocally related to the corresponding change in BBF (r = -0.77, P = 0.015). These findings suggest that a component of the reduction of respiratory neuromotor output during REM is attributable to increased BBF with consequent relative hypocapnia in the central chemoreceptor environment.

Full Text

Cited Authors

  • Parisi, RA; Neubauer, JA; Frank, MM; Santiago, TV; Edelman, NH

Published Date

  • April 1, 1988

Published In

Volume / Issue

  • 64 / 4

Start / End Page

  • 1457 - 1465

PubMed ID

  • 3378981

Pubmed Central ID

  • 3378981

International Standard Serial Number (ISSN)

  • 8750-7587

Digital Object Identifier (DOI)

  • 10.1152/jappl.1988.64.4.1457


  • eng

Conference Location

  • United States