Activated terminal complement in cerebrospinal fluid in Guillain-Barré syndrome and multiple sclerosis.

Journal Article

A quantitative enzyme-linked immunosorbent assay was used to measure the concentration of fluid-phase complement C5b-9 complexes (SC5b-9) in the cerebrospinal fluid (CSF) of 14 patients with acute monophasic Guillain-Barré Syndrome (GBS), 21 patients with multiple sclerosis (MS), and 11 patients with noninflammatory central nervous system (CNS) diseases. SC5b-9 complexes were detected in the CSF of 13 of 14 patients with acute GBS (mean, 3.08 micrograms/ml; range, 0 to 7.1 micrograms/ml) and 16 of 21 patients with MS (mean, 1.83 micrograms/ml; range, 0 to 7.5 micrograms/ml). In the control group of patients with noninflammatory CNS diseases, SC5b-9 was not detected in eight of 11 and was present in low concentrations in the remaining three patients (mean, 0.28 micrograms/ml; range, 0 to 1.7 micrograms/ml). The finding of SC5b-9 complexes in the CSF of patients with GBS and MS suggests that terminal complement components may participate in the tissue-damaging processes in these diseases.

Full Text

Duke Authors

Cited Authors

  • Sanders, ME; Koski, CL; Robbins, D; Shin, ML; Frank, MM; Joiner, KA

Published Date

  • June 15, 1986

Published In

Volume / Issue

  • 136 / 12

Start / End Page

  • 4456 - 4459

PubMed ID

  • 3711661

International Standard Serial Number (ISSN)

  • 0022-1767

Language

  • eng

Conference Location

  • United States