Decline in rates of clearance of IgG-sensitized erythrocytes with increasing age.


Journal Article

Decreased immune functions have been suggested as a cause for the increased incidence of autoimmunity, malignancy, and infection in the elderly population. To assess the possible role of changes in macrophage function in the aging process we studied the Fc receptor-mediated clearance of IgG-coated erythrocytes in 56 healthy normal volunteers by following the removal of radiolabeled autologous erythrocytes. An age-related decrease in Fc-mediated clearance rates in both female and male subjects was found, which suggests a physiological decline of this macrophage function in older individuals.

Full Text

Cited Authors

  • Melez, KA; Fries, LF; Bender, BS; Quinn, T; Frank, MM

Published Date

  • June 1988

Published In

Volume / Issue

  • 71 / 6

Start / End Page

  • 1726 - 1730

PubMed ID

  • 3370316

Pubmed Central ID

  • 3370316

International Standard Serial Number (ISSN)

  • 0006-4971


  • eng

Conference Location

  • United States