Inhibition of the complement cascade by the major secretory protein of vaccinia virus.
Publication
, Journal Article
Kotwal, GJ; Isaacs, SN; McKenzie, R; Frank, MM; Moss, B
Published in: Science
November 9, 1990
The complement system contributes to host defenses against invasion by infectious agents. A 35-kilodalton protein, encoded by vaccinia virus and secreted from infected cells, has sequence similarities to members of a gene family that includes complement control proteins. Biochemical and genetic studies showed that the viral protein binds to derivatives of the fourth component of complement and inhibits the classical complement cascade, suggesting that it serves as a defense molecule to help the virus evade the consequences of complement activation.
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Published In
Science
DOI
ISSN
0036-8075
Publication Date
November 9, 1990
Volume
250
Issue
4982
Start / End Page
827 / 830
Location
United States
Related Subject Headings
- Viral Proteins
- Vaccinia virus
- Restriction Mapping
- Molecular Sequence Data
- Immunoblotting
- Hemolytic Plaque Technique
- General Science & Technology
- Complement Pathway, Classical
- Complement C4b
- Chromatography, Gel
Citation
APA
Chicago
ICMJE
MLA
NLM
Kotwal, G. J., Isaacs, S. N., McKenzie, R., Frank, M. M., & Moss, B. (1990). Inhibition of the complement cascade by the major secretory protein of vaccinia virus. Science, 250(4982), 827–830. https://doi.org/10.1126/science.2237434
Kotwal, G. J., S. N. Isaacs, R. McKenzie, M. M. Frank, and B. Moss. “Inhibition of the complement cascade by the major secretory protein of vaccinia virus.” Science 250, no. 4982 (November 9, 1990): 827–30. https://doi.org/10.1126/science.2237434.
Kotwal GJ, Isaacs SN, McKenzie R, Frank MM, Moss B. Inhibition of the complement cascade by the major secretory protein of vaccinia virus. Science. 1990 Nov 9;250(4982):827–30.
Kotwal, G. J., et al. “Inhibition of the complement cascade by the major secretory protein of vaccinia virus.” Science, vol. 250, no. 4982, Nov. 1990, pp. 827–30. Pubmed, doi:10.1126/science.2237434.
Kotwal GJ, Isaacs SN, McKenzie R, Frank MM, Moss B. Inhibition of the complement cascade by the major secretory protein of vaccinia virus. Science. 1990 Nov 9;250(4982):827–830.
Published In
Science
DOI
ISSN
0036-8075
Publication Date
November 9, 1990
Volume
250
Issue
4982
Start / End Page
827 / 830
Location
United States
Related Subject Headings
- Viral Proteins
- Vaccinia virus
- Restriction Mapping
- Molecular Sequence Data
- Immunoblotting
- Hemolytic Plaque Technique
- General Science & Technology
- Complement Pathway, Classical
- Complement C4b
- Chromatography, Gel