Inhibition of the complement cascade by the major secretory protein of vaccinia virus.


Journal Article

The complement system contributes to host defenses against invasion by infectious agents. A 35-kilodalton protein, encoded by vaccinia virus and secreted from infected cells, has sequence similarities to members of a gene family that includes complement control proteins. Biochemical and genetic studies showed that the viral protein binds to derivatives of the fourth component of complement and inhibits the classical complement cascade, suggesting that it serves as a defense molecule to help the virus evade the consequences of complement activation.

Full Text

Cited Authors

  • Kotwal, GJ; Isaacs, SN; McKenzie, R; Frank, MM; Moss, B

Published Date

  • November 9, 1990

Published In

Volume / Issue

  • 250 / 4982

Start / End Page

  • 827 - 830

PubMed ID

  • 2237434

Pubmed Central ID

  • 2237434

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.2237434


  • eng

Conference Location

  • United States