COMPLEMENT AND HEMOLYTIC ANTIBODY: CHANGES IN THEIR ACTIVITY INDUCED BY MERCAPTOETHANOL.

Published

Journal Article

Cell-bound complement components are not destroyed by mercaptoethanol. Destruction of cell-bound hemolytic antibody was prevented by cell-bound complement components. In the absence of cells, the complement components C'3 and C'4 were most susceptible to destruction by mercaptoethanol; C'1, C'1a, and C'2 were most resistant. Mercaptoethanol (0.01M) increases C'1 activity, and this increase is not due to activation of C'1 to C'1a. Destruction of some components required both mercaptoethanol and iodoacetamide treatment.

Full Text

Cited Authors

  • FRANK, MM; BORSOS, T; RAPP, HJ

Published Date

  • February 12, 1965

Published In

Volume / Issue

  • 147 / 3659

Start / End Page

  • 742 - 743

PubMed ID

  • 14242020

Pubmed Central ID

  • 14242020

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.147.3659.742

Language

  • eng

Conference Location

  • United States