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A serial study of splenic reticuloendothelial system Fc receptor functional activity in systemic lupus erythematosus.

Publication ,  Journal Article
Hamburger, MI; Lawley, TJ; Kimberly, RP; Plotz, PH; Frank, MM
Published in: Arthritis Rheum
January 1982

A serial study of reticuloendothelial system splenic Fc receptor function was undertaken in 13 patients with systemic lupus erythematosus (SLE). Fc receptor function was assessed by measuring the clearance half times of IgG-sensitized 51Cr-labeled autologous erythrocytes from the circulation. Prolonged clearance half times were initially detected in all patients, and the magnitude of the clearance defect was significantly correlated with disease activity (P less than 0.01, Spearman rank correlation) and immune complex levels (P less than 0.01). Clinical course and changes in receptor functional activity over time were found to be significantly correlated. Clearance half-times tended to return to normal in all 11 patients who clinically improved. The clearance half-time remained unchanged in 1 patient whose disease activity was stable, and it worsened in 1 patient whose illness flared. Levels of immune complexes also changed concordantly with clearance half-times and disease activity. These studies underscore the interrelationship between the presence of circulating immune complexes, defects in Fc receptor function that might lead to prolonged circulation of these complexes, and disease activity in SLE.

Published In

Arthritis Rheum

DOI

ISSN

0004-3591

Publication Date

January 1982

Volume

25

Issue

1

Start / End Page

48 / 54

Location

United States

Related Subject Headings

  • Time Factors
  • Spleen
  • Receptors, Fc
  • Mononuclear Phagocyte System
  • Middle Aged
  • Lupus Erythematosus, Systemic
  • Immunoglobulin G
  • Humans
  • Female
  • Erythrocytes
 

Citation

APA
Chicago
ICMJE
MLA
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Hamburger, M. I., Lawley, T. J., Kimberly, R. P., Plotz, P. H., & Frank, M. M. (1982). A serial study of splenic reticuloendothelial system Fc receptor functional activity in systemic lupus erythematosus. Arthritis Rheum, 25(1), 48–54. https://doi.org/10.1002/art.1780250108
Hamburger, M. I., T. J. Lawley, R. P. Kimberly, P. H. Plotz, and M. M. Frank. “A serial study of splenic reticuloendothelial system Fc receptor functional activity in systemic lupus erythematosus.Arthritis Rheum 25, no. 1 (January 1982): 48–54. https://doi.org/10.1002/art.1780250108.
Hamburger MI, Lawley TJ, Kimberly RP, Plotz PH, Frank MM. A serial study of splenic reticuloendothelial system Fc receptor functional activity in systemic lupus erythematosus. Arthritis Rheum. 1982 Jan;25(1):48–54.
Hamburger, M. I., et al. “A serial study of splenic reticuloendothelial system Fc receptor functional activity in systemic lupus erythematosus.Arthritis Rheum, vol. 25, no. 1, Jan. 1982, pp. 48–54. Pubmed, doi:10.1002/art.1780250108.
Hamburger MI, Lawley TJ, Kimberly RP, Plotz PH, Frank MM. A serial study of splenic reticuloendothelial system Fc receptor functional activity in systemic lupus erythematosus. Arthritis Rheum. 1982 Jan;25(1):48–54.
Journal cover image

Published In

Arthritis Rheum

DOI

ISSN

0004-3591

Publication Date

January 1982

Volume

25

Issue

1

Start / End Page

48 / 54

Location

United States

Related Subject Headings

  • Time Factors
  • Spleen
  • Receptors, Fc
  • Mononuclear Phagocyte System
  • Middle Aged
  • Lupus Erythematosus, Systemic
  • Immunoglobulin G
  • Humans
  • Female
  • Erythrocytes