Defective reticuloendothelial system Fc-receptor function in systemic lupus erythematosus.


Journal Article

To determine whether reticuloendothelial-system immunospecific Fc-receptor function is abnormal in patients with systemic lupus erythematosus, we studied the clearance of IgG-sensitized 51Cr-labeled erythrocytes by these splenic macrophage membrane receptors in 15 untreated patients. Fc-specific clearance rates were strikingly abnormal in 13 of 15 patients (half-times ranging from 80 to 2256 minutes, P less than 0.001 as compared to controls). Abnormal clearances correlated with immune-complex levels (as measured by the C1q-binding assay) and with disease activity. C1q-binding activity and anti-DNA titers also correlated with disease activity. The correlations of C3, C4, CH50 and factor B with abnormal clearance and disease activity were weaker or nonexistent. The significant correlations among clearance, disease activity and C1q-binding activity suggest that the defect in Fc-receptor function may lead to the prolonged circulation of immune complexes, thereby contributing to tissue deposition and damage.

Full Text

Cited Authors

  • Frank, MM; Hamburger, MI; Lawley, TJ; Kimberly, RP; Plotz, PH

Published Date

  • March 8, 1979

Published In

Volume / Issue

  • 300 / 10

Start / End Page

  • 518 - 523

PubMed ID

  • 763252

Pubmed Central ID

  • 763252

International Standard Serial Number (ISSN)

  • 0028-4793

Digital Object Identifier (DOI)

  • 10.1056/NEJM197903083001002


  • eng

Conference Location

  • United States