Serum complement and immunity in experimental simian malaria. I. Cyclical alterations in C4 related to schizont rupture.


Journal Article

Previous studies indicated that the level of whole serum complement (C') falls during malaria, and that the fall in C' is linked to schizont rupture and the appearance of humoral antibody. For a more detailed study of the role of C' in malaria, levels of C4 were monitored in rhesus monkeys infected with Plasmodium coatneyi. After one to two weeks of infection, significant and abrupt declines in C4 levels occurred, and these were temporally related to the process of schizont rupture. The level of C4 began to fall within a few hours after the onset of schizont rupture and fell to values as low as 2% of prerupture levels. Over the next 24-36 hr, C4 returned to normal levels, and fell again during the next cycle of schizont rupture. In general, the decline in C4 levels was positively correlated with the onset of immune response (functional and serologic) and degree of parasitemia. This marked cyclincal depletion of C4 indicates tremendous turnover of C' in primates with malaria.

Full Text

Cited Authors

  • Glew, RH; Atkinson, JP; Frank, MM; Collins, WE; Neva, FA

Published Date

  • January 1975

Published In

Volume / Issue

  • 131 / 1

Start / End Page

  • 17 - 25

PubMed ID

  • 1089126

Pubmed Central ID

  • 1089126

International Standard Serial Number (ISSN)

  • 0022-1899

Digital Object Identifier (DOI)

  • 10.1093/infdis/131.1.17


  • eng

Conference Location

  • United States