Increased expression of Fc gamma RI on isolated PMN from individuals of African descent.


Journal Article

Fc gamma R plays an important role in host defense, triggering and/or facilitating many immunologic responses. Of the three defined Fc gamma Rs, Fc gamma RI (CD64) is not known to be constitutively expressed on normal PMN. We report here that there is markedly increased expression of Fc gamma RI on the PMN of normal, healthy blacks, detected by binding of monoclonal antibody to this receptor. This may have significant implications when multiracial data are pooled in studies of receptor expression as markers of response to various chemotherapeutic agents.

Full Text

Cited Authors

  • Moxey-Mims, MM; Frank, MM; Lin, EY; Francis, C; Gaither, TA

Published Date

  • October 1993

Published In

Volume / Issue

  • 69 / 1

Start / End Page

  • 117 - 121

PubMed ID

  • 8403539

Pubmed Central ID

  • 8403539

International Standard Serial Number (ISSN)

  • 0090-1229

Digital Object Identifier (DOI)

  • 10.1006/clin.1993.1158


  • eng

Conference Location

  • United States