Treatment of hereditary angioedema with danazol. Reversal of clinical and biochemical abnormalities.

Published

Journal Article

Danazol, an androgen derivative, was evaluated for its effectiveness in preventing attacks of hereditary angioedema in a double-blind study with nine patients. Of 47 placebo courses, 44 ended with attacks, but during 46 danazol courses only one attack occurred. Side effects were minimal, and virilization was not observed in the women studied. C1 esterase inhibitor levels increased three to four times, and levels of the fourth component of complement (C4) increased 15 times. These changes began during the first day of therapy and were maximal by one to two weeks. After therapy was stopped, C1 esterase inhibitor and C4 levels rapidly decreased. Danazol effectively prevents attacks in hereditary angioedema and acts to correct the underlying biochemical abnormality.

Full Text

Cited Authors

  • Gelfand, JA; Sherins, RJ; Alling, DW; Frank, MM

Published Date

  • December 23, 1976

Published In

Volume / Issue

  • 295 / 26

Start / End Page

  • 1444 - 1448

PubMed ID

  • 792688

Pubmed Central ID

  • 792688

International Standard Serial Number (ISSN)

  • 0028-4793

Digital Object Identifier (DOI)

  • 10.1056/NEJM197612232952602

Language

  • eng

Conference Location

  • United States