Regulation of complement activity by vaccinia virus complement-control protein.

Published

Journal Article

A major protein secreted by vaccinia virus-infected cells has structural similarity to the super-family of complement-control proteins. This vaccinia complement-control protein (VCP) was studied to determine how it regulates complement activation. VCP was bound by C4b and C3b and served as a cofactor with factor I in cleaving these two molecules. VCP inhibited the formation and accelerated the decay of the classical C3 convertase. It also accelerated decay of the alternative pathway convertase, although higher concentrations were apparently needed. In vitro, therefore, VCP interfered with the classical and alternative complement pathways at several steps. In vivo, this interference may increase the virulence of vaccinia virus by enabling it to escape attack by the host's complement system.

Full Text

Cited Authors

  • McKenzie, R; Kotwal, GJ; Moss, B; Hammer, CH; Frank, MM

Published Date

  • December 1992

Published In

Volume / Issue

  • 166 / 6

Start / End Page

  • 1245 - 1250

PubMed ID

  • 1431243

Pubmed Central ID

  • 1431243

International Standard Serial Number (ISSN)

  • 0022-1899

Digital Object Identifier (DOI)

  • 10.1093/infdis/166.6.1245

Language

  • eng

Conference Location

  • United States