Impaired immune response of splenectomised patients to polyvalent pneumococcal vaccine.


Journal Article

Immune response to polyvalent pneumococcal vaccine was measured in normal volunteers and splenectomised patients, by means of a newly developed enzyme-linked immunosorbent assay for pneumococcal antibodies. IgG and IgM responses to eight of the nine polysaccharides tested were markedly impaired in splenectomised patients. The response of splenectomised patients was less than that of the controls in terms of absolute titre of antibody achieved, relative rise in titre (fold increase of post-immunisation titre over pre-immunisation titre), and rate of rise.

Full Text

Cited Authors

  • Hosea, SW; Burch, CG; Brown, EJ; Berg, RA; Frank, MM

Published Date

  • April 1, 1981

Published In

Volume / Issue

  • 1 / 8224

Start / End Page

  • 804 - 807

PubMed ID

  • 6111673

Pubmed Central ID

  • 6111673

Electronic International Standard Serial Number (EISSN)

  • 1474-547X

International Standard Serial Number (ISSN)

  • 0140-6736

Digital Object Identifier (DOI)

  • 10.1016/s0140-6736(81)92681-7


  • eng