Monocyte receptors for the Fc portion of IgG increase in number in autoimmune hemolytic anemia and other hemolytic states and are decreased by glucocorticoid therapy.

Published

Journal Article

Peripheral blood monocyte receptors for the Fc portion of IgG were quantitatively studied in 43 normal subjects, in 14 patients with warm antibody autoimmune hemolysis (AIHA), and in nine individuals with nonantibody-mediated hemolysis. Monocytes of normal females expressed significantly greater numbers of Fc gamma receptors than did similar cells from male subjects, with no difference in affinity for the IgG1 probe. Monocyte Fc gamma receptor number was increased in patients of both sexes with AIHA; a similar, but smaller, increase in monocyte Fc gamma receptor number was noted in patients with nonantibody-mediated hemolysis. Glucocorticoid administration was associated with a dose-dependent decrease in monocyte Fc gamma receptor number in normal volunteers and patients. Possible etiologic mechanisms and pathogenetic consequences of enhanced monocyte Fc gamma binding in AIHA are discussed.

Full Text

Cited Authors

  • Fries, LF; Brickman, CM; Frank, MM

Published Date

  • September 1, 1983

Published In

Volume / Issue

  • 131 / 3

Start / End Page

  • 1240 - 1245

PubMed ID

  • 6224854

Pubmed Central ID

  • 6224854

International Standard Serial Number (ISSN)

  • 0022-1767

Language

  • eng

Conference Location

  • United States