Oral manifestations and dental management of patients with hereditary angioedema.

Published

Journal Article

Hereditary angioedema (HAE) is a genetic disorder in which affected individuals develop extensive, spontaneous angioedema of the extremities, gastrointestinal tract, and oropharynx. Dental treatment of unmedicated patients with HAE can trigger life-threatening pharyngeal edema. Previously, it was demonstrated that the administration of fresh frozen plasma (FFP) before surgery prevented angioedema attacks in 6 patients undergoing dental extractions. The present study examines the long term effectiveness of FFP in preventing angioedema from developing in 53 patients with HAE undergoing all types of dental treatment over a ten-year period. Only 3 of 45 patients (6.7%) covered with FFP had a minor angioedema attack after dental therapy in 10 yr. No attacks of moderate or severe swelling were seen. Attacks occurred independently of the disease activity of the patient and the trauma of the dental procedure. The use of fresh frozen plasma is effective in preventing attacks of angioedema in HAE patients undergoing all types of dental procedures.

Full Text

Cited Authors

  • Atkinson, JC; Frank, MM

Published Date

  • March 1, 1991

Published In

Volume / Issue

  • 20 / 3

Start / End Page

  • 139 - 142

PubMed ID

  • 1828083

Pubmed Central ID

  • 1828083

International Standard Serial Number (ISSN)

  • 0904-2512

Language

  • eng

Conference Location

  • Denmark