C5a stimulates secretion of tumor necrosis factor from human mononuclear cells in vitro. Comparison with secretion of interleukin 1 beta and interleukin 1 alpha.


Journal Article

We have demonstrated that purified C5a is a potent stimulus to human PBMC secretion of TNF-alpha, IL-1 beta, and IL-1 alpha, which proceeds in a dose-dependent fashion. At a given concentration of C5a, TNF-alpha and IL-1 beta secretion did not differ significantly; both were secreted in significantly greater quantity than IL-1 alpha. Clinical conditions such as Gram-positive and Gram-negative bacterial infections, trauma, and immune complex diseases activate complement. Through the mediation of TNF and IL-1 secreted in response to C5a, these diverse disorders can share common features of fever, coagulopathy, acute phase protein production, and disordered metabolism.

Full Text

Cited Authors

  • Okusawa, S; Yancey, KB; van der Meer, JW; Endres, S; Lonnemann, G; Hefter, K; Frank, MM; Burke, JF; Dinarello, CA; Gelfand, JA

Published Date

  • July 1, 1988

Published In

Volume / Issue

  • 168 / 1

Start / End Page

  • 443 - 448

PubMed ID

  • 3260938

Pubmed Central ID

  • 3260938

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.168.1.443


  • eng

Conference Location

  • United States