The contribution of both extracellular and intracellular calcium to the action of alpha-adrenergic agonists in perfused rat liver.
Published
Journal Article
The role of both intracellular and extracellular Ca2+ pools in the expression of alpha-adrenergic-agonist-mediated responses was examined in perfused rat liver. Responses studied included glycogenolysis, respiration, lactate and pyruvate formation, ketone-body production, changes in the cytoplasmic and mitochondrial redox ratio and cellular K+ fluxes. Each of these was shown to be dependent on the mobilization of intracellular Ca2+ and can be grouped into one of two response types. Transient responses (ion fluxes and the redox ratios) are obligatorily dependent on the mobilization of intracellular Ca2+ and occur irrespective of the extracellular Ca2+ concentration. Sustained responses, on the other hand, initially require intracellular Ca2+ and, subsequently, extracellular Ca2+. The data indicate that alpha-adrenergic agonists mobilize extracellular Ca2+ as well as intracellular Ca2+ and that both pools are required for the full expression of hormone-induced responses in rat liver.
Full Text
Cited Authors
- Reinhart, PH; Taylor, WM; Bygrave, FL
Published Date
- May 1, 1984
Published In
Volume / Issue
- 220 / 1
Start / End Page
- 35 - 42
PubMed ID
- 6743271
Pubmed Central ID
- 6743271
Electronic International Standard Serial Number (EISSN)
- 1470-8728
International Standard Serial Number (ISSN)
- 0264-6021
Digital Object Identifier (DOI)
- 10.1042/bj2200035
Language
- eng