Abnormal ion permeation through cystic fibrosis respiratory epithelium.


Journal Article

The epithelium of nasal tissue excised from subjects with cystic fibrosis exhibited higher voltage and lower conductance than tissue from control subjects. Basal sodium ion absorption by cystic fibrosis and normal nasal epithelia equaled the short-circuit current and was amiloride-sensitive. Amiloride induced chloride ion secretion in normal but not cystic fibrosis tissue and consequently was more effective in inhibiting the short-circuit current in cystic fibrosis epithelia. Chloride ion-free solution induced a smaller hyperpolarization of cystic fibrosis tissue. The increased voltage and amiloride efficacy in cystic fibrosis reflect absorption of sodium ions across an epithelium that is relatively impermeable to chloride ions.

Full Text

Cited Authors

  • Knowles, MR; Stutts, MJ; Spock, A; Fischer, N; Gatzy, JT; Boucher, RC

Published Date

  • September 9, 1983

Published In

Volume / Issue

  • 221 / 4615

Start / End Page

  • 1067 - 1070

PubMed ID

  • 6308769

Pubmed Central ID

  • 6308769

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.6308769


  • eng

Conference Location

  • United States