Hepatic parenchymal cells in cystic fibrosis: ultrastructural evidence for abnormal intracellular transport.

Journal Article (Journal Article)

Few ultrastructural observations of hepatic parenchymal cells in cystic fibrosis (CF) have appeared in the literature. Utilizing a unique opportunity to examine freshly fixed hepatic tissue by transmission electron microscopy, we studied 12 patients dying with CF at Duke Hospital from 1979 to 1981 in order to identify possible abnormalities of intracellular architecture. The major findings include (1) intracellular fatty vacuoles, (2) distended bile ductules and bile ducts containing increased cellular debris, (3) profiles of distended rough endoplasmic reticulum containing material of medium electron density, and (4) membrane-bound deposits of electron-lucent material containing electron-dense cores resembling mucus. We suggest that the material seen within the cytocavitary network reflects a derangement of intracellular transport.

Full Text

Duke Authors

Cited Authors

  • Bradford, W; Allen, D; Shelburne, J; Spock, A

Published Date

  • 1983

Published In

Volume / Issue

  • 1 / 3

Start / End Page

  • 269 - 279

PubMed ID

  • 6687280

International Standard Serial Number (ISSN)

  • 0277-0938

Digital Object Identifier (DOI)

  • 10.3109/15513818309040664


  • eng

Conference Location

  • United States