Mechanism of fast protein folding.
Publication
, Journal Article
Myers, JK; Oas, TG
Published in: Annu Rev Biochem
2002
An explosion of in vitro experimental data on the folding of proteins has revealed many examples of folding in the millisecond or faster timescale, often occurring in the absence of stable intermediate states. We review experimental methods for measuring fast protein folding kinetics, and then discuss various analytical models used to interpret these data. Finally, we classify general mechanisms that have been proposed to explain fast protein folding into two catagories, heterogeneous and homogeneous, reflecting the nature of the transition state. One heterogeneous mechanism, the diffusion-collision mechanism, can be used to interpret experimental data for a number of proteins.
Duke Scholars
Published In
Annu Rev Biochem
DOI
ISSN
0066-4154
Publication Date
2002
Volume
71
Start / End Page
783 / 815
Location
United States
Related Subject Headings
- Solvents
- Proteins
- Protein Structure, Tertiary
- Protein Structure, Secondary
- Protein Folding
- Models, Theoretical
- Magnetic Resonance Spectroscopy
- Electron Spin Resonance Spectroscopy
- Biochemistry & Molecular Biology
- 3101 Biochemistry and cell biology
Citation
APA
Chicago
ICMJE
MLA
NLM
Myers, J. K., & Oas, T. G. (2002). Mechanism of fast protein folding. Annu Rev Biochem, 71, 783–815. https://doi.org/10.1146/annurev.biochem.71.110601.135346
Myers, Jeffrey K., and Terrence G. Oas. “Mechanism of fast protein folding.” Annu Rev Biochem 71 (2002): 783–815. https://doi.org/10.1146/annurev.biochem.71.110601.135346.
Myers JK, Oas TG. Mechanism of fast protein folding. Annu Rev Biochem. 2002;71:783–815.
Myers, Jeffrey K., and Terrence G. Oas. “Mechanism of fast protein folding.” Annu Rev Biochem, vol. 71, 2002, pp. 783–815. Pubmed, doi:10.1146/annurev.biochem.71.110601.135346.
Myers JK, Oas TG. Mechanism of fast protein folding. Annu Rev Biochem. 2002;71:783–815.
Published In
Annu Rev Biochem
DOI
ISSN
0066-4154
Publication Date
2002
Volume
71
Start / End Page
783 / 815
Location
United States
Related Subject Headings
- Solvents
- Proteins
- Protein Structure, Tertiary
- Protein Structure, Secondary
- Protein Folding
- Models, Theoretical
- Magnetic Resonance Spectroscopy
- Electron Spin Resonance Spectroscopy
- Biochemistry & Molecular Biology
- 3101 Biochemistry and cell biology