A peptide model of a protein folding intermediate.


Journal Article

It is difficult to determine the structures of protein folding intermediates because folding is a highly cooperative process. A disulphide-bonded peptide pair, designed to mimic the first crucial intermediate in the folding of bovine pancreatic trypsin inhibitor, contains secondary and tertiary structure similar to that found in the native protein. Peptide models like this circumvent the problem of cooperativity and permit characterization of structures of folding intermediates.

Full Text

Duke Authors

Cited Authors

  • Oas, TG; Kim, PS

Published Date

  • November 3, 1988

Published In

Volume / Issue

  • 336 / 6194

Start / End Page

  • 42 - 48

PubMed ID

  • 3185721

Pubmed Central ID

  • 3185721

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/336042a0


  • eng

Conference Location

  • England