A multigene family encoding a diverse array of putative pheromone receptors in mammals.

Journal Article (Journal Article)

The vomeronasal organ of mammals is an olfactory sensory structure that detects pheromones. It contains two subsets of sensory neurons that differentially express G alpha(o) and G alpha(i2). By comparing gene expression in single neurons, we identified a novel multigene family that codes for a diverse array of candidate pheromone receptors (VRs) expressed by the G alpha(o)+ subset. Different VRs are expressed by different neurons, but those neurons are interspersed, suggesting a distributed mode of sensory coding. Chromosome mapping experiments suggest an evolutionary connection between genes encoding VRs and receptors for volatile odorants. However, a dramatically different structure for VRs and the existence of variant VR mRNA forms indicate that there are diverse strategies to detect functionally distinct sensory stimuli.

Full Text

Duke Authors

Cited Authors

  • Matsunami, H; Buck, LB

Published Date

  • August 22, 1997

Published In

Volume / Issue

  • 90 / 4

Start / End Page

  • 775 - 784

PubMed ID

  • 9288756

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/s0092-8674(00)80537-1


  • eng

Conference Location

  • United States