Transgenic mice expressing a constitutively active retinoic acid receptor in the lens exhibit ocular defects.
Publication
, Journal Article
Balkan, W; Klintworth, GK; Bock, CB; Linney, E
Published in: Dev Biol
June 1992
Retinoic acid receptors (RARs) modulate gene expression following association with retinoic acid (RA). In transient transfection, an RAR alpha-beta-galactosidase fusion protein (RAR-LacZ) was able to transactivate expression in the absence of RA. When expressed in the ocular lens of transgenic mice, this constitutively active RAR-LacZ fusion gene resulted in founder and progeny animals that exhibited cataracts and microphthalmia, both being characteristics of retinoid-induced teratogenesis. The transgenic phenotypes indicate that retinoid teratogenesis can be mimicked by expression of a constitutively active RAR-LacZ fusion protein in retinoid-sensitive tissues.
Duke Scholars
Published In
Dev Biol
DOI
ISSN
0012-1606
Publication Date
June 1992
Volume
151
Issue
2
Start / End Page
622 / 625
Location
United States
Related Subject Headings
- Tretinoin
- Trans-Activators
- Recombinant Fusion Proteins
- Receptors, Retinoic Acid
- Molecular Sequence Data
- Microphthalmos
- Mice, Transgenic
- Mice
- Lens, Crystalline
- Lac Operon
Citation
APA
Chicago
ICMJE
MLA
NLM
Balkan, W., Klintworth, G. K., Bock, C. B., & Linney, E. (1992). Transgenic mice expressing a constitutively active retinoic acid receptor in the lens exhibit ocular defects. Dev Biol, 151(2), 622–625. https://doi.org/10.1016/0012-1606(92)90200-z
Balkan, W., G. K. Klintworth, C. B. Bock, and E. Linney. “Transgenic mice expressing a constitutively active retinoic acid receptor in the lens exhibit ocular defects.” Dev Biol 151, no. 2 (June 1992): 622–25. https://doi.org/10.1016/0012-1606(92)90200-z.
Balkan W, Klintworth GK, Bock CB, Linney E. Transgenic mice expressing a constitutively active retinoic acid receptor in the lens exhibit ocular defects. Dev Biol. 1992 Jun;151(2):622–5.
Balkan, W., et al. “Transgenic mice expressing a constitutively active retinoic acid receptor in the lens exhibit ocular defects.” Dev Biol, vol. 151, no. 2, June 1992, pp. 622–25. Pubmed, doi:10.1016/0012-1606(92)90200-z.
Balkan W, Klintworth GK, Bock CB, Linney E. Transgenic mice expressing a constitutively active retinoic acid receptor in the lens exhibit ocular defects. Dev Biol. 1992 Jun;151(2):622–625.
Published In
Dev Biol
DOI
ISSN
0012-1606
Publication Date
June 1992
Volume
151
Issue
2
Start / End Page
622 / 625
Location
United States
Related Subject Headings
- Tretinoin
- Trans-Activators
- Recombinant Fusion Proteins
- Receptors, Retinoic Acid
- Molecular Sequence Data
- Microphthalmos
- Mice, Transgenic
- Mice
- Lens, Crystalline
- Lac Operon