mig-14 is a horizontally acquired, host-induced gene required for salmonella enterica lethal infection in the murine model of typhoid fever.

Published

Journal Article

We have characterized a host-induced virulence gene, mig-14, that is required for fatal infection in the mouse model of enteric fever. mig-14 is present in all Salmonella enterica subspecies I serovars and maps to a region of the chromosome that appears to have been acquired by horizontal transmission. A mig-14 mutant replicated in host tissues early after infection but was later cleared from the spleens and livers of infected animals. Bacterial clearance by the host occurred concomitantly with an increase in gamma interferon levels and recruitment of macrophages, but few neutrophils, to the infection foci. We hypothesize that the mig-14 gene product may repress immune system functions by interfering with normal cytokine expression in response to bacterial infections.

Full Text

Duke Authors

Cited Authors

  • Valdivia, RH; Cirillo, DM; Lee, AK; Bouley, DM; Falkow, S

Published Date

  • December 2000

Published In

Volume / Issue

  • 68 / 12

Start / End Page

  • 7126 - 7131

PubMed ID

  • 11083839

Pubmed Central ID

  • 11083839

International Standard Serial Number (ISSN)

  • 0019-9567

Digital Object Identifier (DOI)

  • 10.1128/iai.68.12.7126-7131.2000

Language

  • eng

Conference Location

  • United States