Autism and mental retardation: neuropathologic studies performed in four retarded persons with autistic behavior.


Journal Article

Four persons who exhibited prominent autistic features throughout life died when 4, 14, 27, and 33 years old. All were mentally retarded. One had documented phenylketonuria, but the cause of mental retardation and autistic behavior was undefined in three. At the time of autopsy, brain weights were within 2 SDs of the norm for age. Complete neuropathologic examination, including analysis of cortical neurons impregnated with the rapid Golgi method, failed to provide clues as to cause or the pathoanatomic substrate of autistic behavior in these cases.

Full Text

Cited Authors

  • Williams, RS; Hauser, SL; Purpura, DP; DeLong, GR; Swisher, CN

Published Date

  • December 1, 1980

Published In

Volume / Issue

  • 37 / 12

Start / End Page

  • 749 - 753

PubMed ID

  • 7447762

Pubmed Central ID

  • 7447762

International Standard Serial Number (ISSN)

  • 0003-9942

Digital Object Identifier (DOI)

  • 10.1001/archneur.1980.00500610029003


  • eng

Conference Location

  • United States