Acquired reversible autistic syndrome in acute encephalopathic illness in children.

Published

Journal Article

In seeking the neurologic substrate of the autistic syndrome of childhood, previous studies have implicated the medial temporal lobe or the ring of mesolimbic cortex located in the mesial frontal and temporal lobes. During an acute encephalopathic illness, a clinical picture developed in three children that was consistent with infantile autism. This development was reversible. It was differentiated from acquired epileptic aphasia, and the language disorder was differentiated aphasia. One child has rises in serum herpes simplex titers, and a computerized tomographic (CT) scan revealed an extensive lesion of the temporal lobes, predominantly on the left. The other two, with similar clinical syndromes, had normal CT scans, and no etiologic agent was defined. These cases are examples of an acquired and reversible autistic syndrome in childhood, emphasizing the clinical similarities to bilateral medial temporal lobe disease as described in man, including the Klüver-Bucy syndrome seen in postencephalitic as well as postsurgical states.

Full Text

Cited Authors

  • DeLong, GR; Bean, SC; Brown, FR

Published Date

  • March 1, 1981

Published In

Volume / Issue

  • 38 / 3

Start / End Page

  • 191 - 194

PubMed ID

  • 6162440

Pubmed Central ID

  • 6162440

International Standard Serial Number (ISSN)

  • 0003-9942

Digital Object Identifier (DOI)

  • 10.1001/archneur.1981.00510030085013

Language

  • eng

Conference Location

  • United States