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Quality-assurance study of simultaneously sampled, non-correlating cervical cytology and biopsies.

Publication ,  Journal Article
Dodd, LG; Sneige, N; Villarreal, Y; Fanning, CV; Staerkel, GA; Caraway, NP; Silva, EG; Katz, RL
Published in: Diagn Cytopathol
1993

As part of a quality assurance study, we reviewed 223 cases of simultaneously sampled cervical smears and biopsies that showed a significant lack of correlation for squamous dysplasia or carcinoma. In 153 of the 223 cases (68.6%), the cytology was negative and the biopsy positive. After review of the specimens, errors in this group were found to be of the following types: sampling 64%, interpretive 29%, and combined sampling and interpretive 7%. In the remaining 70 cases (31.4%), the biopsy was negative and the Papanicolaou smear positive. In these cases, the following types of errors occurred: sampling 54%, interpretive 33%, and combination 13%. Twenty-nine of these 70 patients showed dysplasia on follow-up material. These findings indicate there are a significant number of false-negative Papanicolaou smears, mostly because of sampling problems. There are few false-positives. In cases of positive Papanicolaou and negative biopsy, dysplasia is likely to be present in subsequent samples.

Duke Scholars

Published In

Diagn Cytopathol

DOI

ISSN

8755-1039

Publication Date

1993

Volume

9

Issue

2

Start / End Page

138 / 144

Location

United States

Related Subject Headings

  • Vaginal Smears
  • Uterine Cervical Neoplasms
  • Uterine Cervical Dysplasia
  • Time Factors
  • Retrospective Studies
  • Quality Assurance, Health Care
  • Predictive Value of Tests
  • Pathology
  • Papanicolaou Test
  • Humans
 

Citation

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MLA
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Dodd, L. G., Sneige, N., Villarreal, Y., Fanning, C. V., Staerkel, G. A., Caraway, N. P., … Katz, R. L. (1993). Quality-assurance study of simultaneously sampled, non-correlating cervical cytology and biopsies. Diagn Cytopathol, 9(2), 138–144. https://doi.org/10.1002/dc.2840090206
Dodd, L. G., N. Sneige, Y. Villarreal, C. V. Fanning, G. A. Staerkel, N. P. Caraway, E. G. Silva, and R. L. Katz. “Quality-assurance study of simultaneously sampled, non-correlating cervical cytology and biopsies.Diagn Cytopathol 9, no. 2 (1993): 138–44. https://doi.org/10.1002/dc.2840090206.
Dodd LG, Sneige N, Villarreal Y, Fanning CV, Staerkel GA, Caraway NP, et al. Quality-assurance study of simultaneously sampled, non-correlating cervical cytology and biopsies. Diagn Cytopathol. 1993;9(2):138–44.
Dodd, L. G., et al. “Quality-assurance study of simultaneously sampled, non-correlating cervical cytology and biopsies.Diagn Cytopathol, vol. 9, no. 2, 1993, pp. 138–44. Pubmed, doi:10.1002/dc.2840090206.
Dodd LG, Sneige N, Villarreal Y, Fanning CV, Staerkel GA, Caraway NP, Silva EG, Katz RL. Quality-assurance study of simultaneously sampled, non-correlating cervical cytology and biopsies. Diagn Cytopathol. 1993;9(2):138–144.
Journal cover image

Published In

Diagn Cytopathol

DOI

ISSN

8755-1039

Publication Date

1993

Volume

9

Issue

2

Start / End Page

138 / 144

Location

United States

Related Subject Headings

  • Vaginal Smears
  • Uterine Cervical Neoplasms
  • Uterine Cervical Dysplasia
  • Time Factors
  • Retrospective Studies
  • Quality Assurance, Health Care
  • Predictive Value of Tests
  • Pathology
  • Papanicolaou Test
  • Humans