Fine-needle aspiration cytology of pseudosarcomatous lesions of soft tissue.


Journal Article (Review)

Pseudosarcomatous lesions are benign neoplasms of the musculoskeletal system that are likely to be misdiagnosed as malignant, based on clinical and histologic features. These include soft-tissue "tumors" considered reactive or reparative lesions such as nodular fasciitis and myositis ossificans. Also included in the "pseudosarcoma" category are benign neoplasms which show "pseudoanaplastic" cytologic atypia. The latter include lipoma, leiomyoma, angiomyolipoma, and benign peripheral nerve-sheath tumors. These neoplasms, particularly the reparative processes and the nerve sheath tumors, are increasingly being subjected to initial diagnosis by fine-needle aspiration cytology. Even by conventional cytology this group of lesions represents a well-known pitfall for the diagnostic pathologist. We review some cytologic features: repair-like change, cohesion of cellular fragments, and presence of "normal" elements in the aspirate, which may help the cytopathologist avoid misdiagnosis of these notoriously difficult entities.

Full Text

Duke Authors

Cited Authors

  • Dodd, LG; Martinez, S

Published Date

  • January 2001

Published In

Volume / Issue

  • 24 / 1

Start / End Page

  • 28 - 35

PubMed ID

  • 11135465

Pubmed Central ID

  • 11135465

International Standard Serial Number (ISSN)

  • 8755-1039

Digital Object Identifier (DOI)

  • 10.1002/1097-0339(200101)24:1<28::aid-dc1004>;2-g


  • eng

Conference Location

  • United States