Scanning electron microscopy and X-ray microanalysis of foreign bodies associated with Silastic implants in humans.

Journal Article (Journal Article)

Polydimethylsiloxane (Silastic) capsules containing megestrol acetate have been implanted in subcutaneous tissue as a method of long-term contraception. Histological studies revealed a granulomatous foreign body reaction around these capsules with birefringent crystals in multinucleated giant cells. Although several authors had interpreted these crystals as steroids, this seemed unlikely since the tissue had been processed with organic solvents. Analysis of these crystals by polarization microscopy, scanning electron microscopy, and X-ray microanalysis demonstrated that the material was talc. The talc was probably introduced as a contaminant from gloves during the implantation. Further analysis showed that capsule fragmentation could not have produced the material since Silastic particles could not be detected.

Full Text

Duke Authors

Cited Authors

  • Tatum, AH; Shelburne, JD; Ingram, P; Robertson, DN; Croxatto, HB; Diaz, S

Published Date

  • December 1, 1983

Published In

Volume / Issue

  • 28 / 6

Start / End Page

  • 543 - 552

PubMed ID

  • 6370587

International Standard Serial Number (ISSN)

  • 0010-7824

Digital Object Identifier (DOI)

  • 10.1016/0010-7824(83)90105-1


  • eng

Conference Location

  • United States