Intercellular junctions and tumor stage in small cell carcinoma of the lung.

Journal Article (Journal Article)

The authors have studied the ultrastructural features of 52 cases of oat cell carcinoma of the lung and have related their observations to tumor stage and patient survival. Only the type of cell junctions seems to be of prognostic importance. Tumors with intermediate junctions--and especially those with desmosomes--have a more localized stage and may be resectable to result in longer survival than expected for oat cell carcinomas without junctions. For example, in the authors' series the median survival periods for those with no identifiable junctions, intermediate junctions, or desmosomes were 6.4, 8.2, and 11.3 months, respectively. Nevertheless, this ultrastructural subclassification is not as effective as that obtained from careful clinical staging.

Full Text

Duke Authors

Cited Authors

  • Vollmer, RT; Shelburne, JD; Iglehart, JD

Published Date

  • January 1987

Published In

Volume / Issue

  • 18 / 1

Start / End Page

  • 22 - 27

PubMed ID

  • 3028926

International Standard Serial Number (ISSN)

  • 0046-8177

Digital Object Identifier (DOI)

  • 10.1016/s0046-8177(87)80188-0


  • eng

Conference Location

  • United States