Special techniques in diagnostic electron microscopy.

Journal Article (Journal Article;Review)

The power of electron microscopy as a diagnostic tool can be amplified considerably by the application of ancillary preparative and analytic methods. Subcellular chemistry and structure can be examined by various forms of microprobe analysis and by special staining methods, including cytochemical, immunocytochemical, and negative staining. Qualitative ultrastructural examination can be augmented by morphometric analysis. Correlative microscopic survey methods can be used as a means of targeting ultrastructural investigations. This article provides an overview of the use of these special techniques in the diagnosis and classification of tumors and other selected pathologic processes.

Full Text

Duke Authors

Cited Authors

  • Howell, DN; Payne, CM; Miller, SE; Shelburne, JD

Published Date

  • December 1998

Published In

Volume / Issue

  • 29 / 12

Start / End Page

  • 1339 - 1346

PubMed ID

  • 9865818

Pubmed Central ID

  • PMC7131633

International Standard Serial Number (ISSN)

  • 0046-8177

Digital Object Identifier (DOI)

  • 10.1016/s0046-8177(98)90001-6


  • eng

Conference Location

  • United States