Studies on cellular autophagocytosis. Cyclic AMP- and dibutyryl cyclic AMP-stimulated autophagy in rat liver.

Published

Journal Article

Intraperitoneal injections of either cyclic AMP or dibutyryl cyclic AMP are capable of producing a wave of autophagy in rat liver which resembles closely that stimulated by glucagon. These autophagic vacuoles are acid-phosphatase-positive and appear to arise via the envelopment of organelles by double-walled cisterna. At later times these autophagic vacuoles are usually surrounded by a single membrane. Injection of equimolar amounts of 5'-AMP failed to produce a wave of autophagy. These findings constitute preliminary evidence that glucagon-stimulated autophagy is mediated at least in part by cyclic AMP.

Full Text

Duke Authors

Cited Authors

  • Shelburne, JD; Arstila, AU; Trump, BF

Published Date

  • September 1, 1973

Published In

Volume / Issue

  • 72 / 3

Start / End Page

  • 521 - 540

PubMed ID

  • 4125701

Pubmed Central ID

  • 4125701

International Standard Serial Number (ISSN)

  • 0002-9440

Language

  • eng

Conference Location

  • United States