Studies on cellular autophagocytosis. Cyclic AMP- and dibutyryl cyclic AMP-stimulated autophagy in rat liver.
Journal Article (Journal Article)
Intraperitoneal injections of either cyclic AMP or dibutyryl cyclic AMP are capable of producing a wave of autophagy in rat liver which resembles closely that stimulated by glucagon. These autophagic vacuoles are acid-phosphatase-positive and appear to arise via the envelopment of organelles by double-walled cisterna. At later times these autophagic vacuoles are usually surrounded by a single membrane. Injection of equimolar amounts of 5'-AMP failed to produce a wave of autophagy. These findings constitute preliminary evidence that glucagon-stimulated autophagy is mediated at least in part by cyclic AMP.
Full Text
Duke Authors
Cited Authors
- Shelburne, JD; Arstila, AU; Trump, BF
Published Date
- September 1, 1973
Published In
Volume / Issue
- 72 / 3
Start / End Page
- 521 - 540
PubMed ID
- 4125701
Pubmed Central ID
- PMC1904032
International Standard Serial Number (ISSN)
- 0002-9440
Language
- eng
Conference Location
- United States