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Congenital endodermal heterotopia of the atrioventricular node: evidence for the endodermal origin of so-called mesotheliomas of the atrioventricular node.

Publication ,  Journal Article
Linder, J; Shelburne, JD; Sorge, JP; Whalen, RE; Hackel, DB
Published in: Hum Pathol
November 1984

A case of so-called mesothelioma of the atrioventricular node is presented. Controversy exists as to whether this lesion is of mesodermal or endodermal origin. The light and electron microscopic morphologic characteristics in this case were identical to those reported previously. The glandular component produced mucin that resisted digestion with both hyaluronidase and diastase; this staining pattern is characteristic of endodermal rather than of mesodermal tissue. Immunohistochemical methods demonstrated abundant carcinoembryonic antigen (CEA) in the cytoplasm of the cells composing the lesion. The presence of CEA strongly argues for an endodermal origin, since this antigen characterizes tissue derived from endoderm and is generally absent from mesoderm. The lesion probably represents endodermal foregut tissue that is displaced during embryogenesis. As such, it is not a true neoplasm. It is proposed that this lesion be designated "congenital endodermal heterotopia of the atrioventricular node."

Duke Scholars

Published In

Hum Pathol

DOI

ISSN

0046-8177

Publication Date

November 1984

Volume

15

Issue

11

Start / End Page

1093 / 1098

Location

United States

Related Subject Headings

  • Pathology
  • Middle Aged
  • Microscopy, Electron
  • Mesothelioma
  • Immunoenzyme Techniques
  • Humans
  • Heart Neoplasms
  • Heart Conduction System
  • Female
  • Carcinoembryonic Antigen
 

Citation

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Linder, J., Shelburne, J. D., Sorge, J. P., Whalen, R. E., & Hackel, D. B. (1984). Congenital endodermal heterotopia of the atrioventricular node: evidence for the endodermal origin of so-called mesotheliomas of the atrioventricular node. Hum Pathol, 15(11), 1093–1098. https://doi.org/10.1016/s0046-8177(84)80255-5
Linder, J., J. D. Shelburne, J. P. Sorge, R. E. Whalen, and D. B. Hackel. “Congenital endodermal heterotopia of the atrioventricular node: evidence for the endodermal origin of so-called mesotheliomas of the atrioventricular node.Hum Pathol 15, no. 11 (November 1984): 1093–98. https://doi.org/10.1016/s0046-8177(84)80255-5.
Linder, J., et al. “Congenital endodermal heterotopia of the atrioventricular node: evidence for the endodermal origin of so-called mesotheliomas of the atrioventricular node.Hum Pathol, vol. 15, no. 11, Nov. 1984, pp. 1093–98. Pubmed, doi:10.1016/s0046-8177(84)80255-5.
Journal cover image

Published In

Hum Pathol

DOI

ISSN

0046-8177

Publication Date

November 1984

Volume

15

Issue

11

Start / End Page

1093 / 1098

Location

United States

Related Subject Headings

  • Pathology
  • Middle Aged
  • Microscopy, Electron
  • Mesothelioma
  • Immunoenzyme Techniques
  • Humans
  • Heart Neoplasms
  • Heart Conduction System
  • Female
  • Carcinoembryonic Antigen