Hemidesmosome-like intercellular specializations in human meningiomas.

Journal Article (Journal Article)

Desmosomes, gap junctions and tight junctions are intercellular specializations which have been described in human meningiomas. We report, in five of five meningiomas, including a pulmonary metastasis from a malignant intracranial meningioma, a fourth type of intercellular specialization which is similar to but not identical with the hemidesmosome of the epidermis. Idential intercellular specializations have been described between arachnoidal cells, but not between dural fibroblasts. The presence of the junction in human meningeal neoplasms of diverse histologic pattern supports the origin of the meningioma from arachnoidal epithelium. The consistent occurrence of these structures in a pulmonary metastasis as well as benign intracranial tumors suggests that they may be a useful morphologic marker in the differential diagnosis of putative extracranial metastatic meningiomas.

Full Text

Duke Authors

Cited Authors

  • Copeland, DD; Bell, SW; Shelburne, JD

Published Date

  • June 1978

Published In

Volume / Issue

  • 41 / 6

Start / End Page

  • 2242 - 2249

PubMed ID

  • 657090

International Standard Serial Number (ISSN)

  • 0008-543X

Digital Object Identifier (DOI)

  • 10.1002/1097-0142(197806)41:6<2242::aid-cncr2820410625>3.0.co;2-u


  • eng

Conference Location

  • United States