Rocky mountain spotted fever: hepatic lesions in childhood cases.


Journal Article

We studied 16 fatal childhood cases of Rocky Mountain spotted fever (RMSF). Hepatic histologic lesions with statistically significant differences from age- and sex-matched controls were portal triaditis consisting of polymorphonuclear leukocytes and large mononuclear cells, portal vasculitis, sinusoidal leukocytosis, erythrophagocytosis by Kupffer cells, and gross hepatic weight. Hepatocellular necrosis, cholestasis, and congestion were not more frequent in RMSF than in controls. Using immunofluorescence microscopy, we were able to demonstrate rickettsial organisms in portal blood vessels and sinusoidal lining cells of 7 cases.

Full Text

Duke Authors

Cited Authors

  • Jackson, MD; Kirkman, C; Bradford, WD; Walker, DH

Published Date

  • 1986

Published In

Volume / Issue

  • 5 / 3-4

Start / End Page

  • 379 - 388

PubMed ID

  • 3537996

Pubmed Central ID

  • 3537996

International Standard Serial Number (ISSN)

  • 0277-0938

Digital Object Identifier (DOI)

  • 10.3109/15513818609068864


  • eng

Conference Location

  • United States