Multiple congenital septal atresias of the intestine: histomorphologic and pathogenetic implications.

Journal Article (Journal Article)

Congenital atresias of the gastrointestinal tract are usually single and divided into three forms on a morphologic basis. The septal or diaphragmatic type (type I) is the least common. We report an infant with multiple type I atresias involving both the small and large intestine and describe the unique histologic features of the septa: fragmentation of muscularis mucosa, multiple septal cysts lined by columnar epithelium, circular and longitudinal muscular layers, and absence of inflammation. This infant had a sibling who died with multiple intestinal atresias of the septal type. The histologic features suggest that type I gastrointestinal atresias may be due to failure of complete recanalization rather than result from healing of vascular of inflammatory events.

Full Text

Duke Authors

Cited Authors

  • Kao, KJ; Fleischer, R; Bradford, WD; Woodard, BH

Published Date

  • October 1, 1983

Published In

Volume / Issue

  • 1 / 4

Start / End Page

  • 443 - 448

PubMed ID

  • 6687294

International Standard Serial Number (ISSN)

  • 0277-0938

Digital Object Identifier (DOI)

  • 10.3109/15513818309025876


  • eng

Conference Location

  • United States