The steroid profile of a virilizing ovarian tumor.

Journal Article (Journal Article)

A case report of a 25-year-old female with a sex cord stromal virilizing ovarian tumor is presented. The pathway of ovarian steroid secretion in this tumor is elucidated with the dominant elements being pregnenolone, 17-hydroxypregnenolone, 17-hydroxyprogesterone, androstenedione, and testosterone. The tumor primarily made testosterone (T) with lesser elevations of androstenedione (A), dehydroepiandrosterone (DHEA), and dihydrotestosterone (DHT). Expert pathologic opinions differed whether this neoplasm was a Sertoli-Leydig tumor or a virilizing granulosa tumor; therefore, it was probably a gynandroblastoma. A unilateral salpingo-oophorectomy was performed and the patient promptly resumed normal ovarian function with ovulation.

Full Text

Duke Authors

Cited Authors

  • Soules, MR; Abraham, GE; Bossen, EH

Published Date

  • July 1, 1978

Published In

Volume / Issue

  • 52 / 1

Start / End Page

  • 73 - 78

PubMed ID

  • 150557

International Standard Serial Number (ISSN)

  • 0029-7844


  • eng

Conference Location

  • United States