A disease locus for hereditary haemorrhagic telangiectasia maps to chromosome 9q33-34.

Journal Article (Journal Article)

Hereditary haemorrhagic telangiectasia (HHT), or Osler-Weber-Rendu disease, is an autosomal dominant vascular dysplasia of unknown pathogenesis leading to 'widespread' dermal, mucosal and visceral telangiectases and recurrent haemorrhage. We have mapped the HHT gene, by linkage analysis, to markers on 9q33-34 in two large multi-generation families. Haplotype analysis and mapping of recombination breakpoints gives a 4 cM interval between D9S61 and D9S63 as the most likely location of the gene. The closest marker, D9S65, is estimated to be within 1 cM of the gene and shows a combined lod score of 11.41. Two potential candidate genes, COL5A1 and ZNF79, are also located within 9q33-34. These results provide a starting point for the eventual cloning of the HHT gene.

Full Text

Duke Authors

Cited Authors

  • McDonald, MT; Papenberg, KA; Ghosh, S; Glatfelter, AA; Biesecker, BB; Helmbold, EA; Markel, DS; Zolotor, A; McKinnon, WC; Vanderstoep, JL

Published Date

  • February 1994

Published In

Volume / Issue

  • 6 / 2

Start / End Page

  • 197 - 204

PubMed ID

  • 8162075

International Standard Serial Number (ISSN)

  • 1061-4036

Digital Object Identifier (DOI)

  • 10.1038/ng0294-197


  • eng

Conference Location

  • United States