Signal transduction cascades regulating mating, filamentation, and virulence in Cryptococcus neoformans.


Journal Article (Review)

Cryptococcus neoformans is a basidiomycetous fungal pathogen that infects the central nervous system. The organism has a defined sexual cycle involving mating between haploid MATalpha and MATa cells. Recent studies have revealed signaling cascades that coordinately regulate differentiation and virulence of C. neoformans. One signaling cascade involves a conserved G-protein alpha subunit and cAMP, and senses nutrients during mating and virulence. The second is a conserved mitogen activated protein (MAP) kinase cascade that senses pheromone during mating, and also regulates haploid fruiting and virulence. Interestingly, some of the MAP kinase components are encoded by the MAT locus itself, which may explain the unique association of the MATalpha locus with physiology and virulence.

Full Text

Duke Authors

Cited Authors

  • Wang, P; Heitman, J

Published Date

  • August 1999

Published In

Volume / Issue

  • 2 / 4

Start / End Page

  • 358 - 362

PubMed ID

  • 10458985

Pubmed Central ID

  • 10458985

International Standard Serial Number (ISSN)

  • 1369-5274

Digital Object Identifier (DOI)

  • 10.1016/S1369-5274(99)80063-0


  • eng

Conference Location

  • England