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The Cryptococcus neoformans genome sequencing project.

Publication ,  Journal Article
Heitman, J; Casadevall, A; Lodge, JK; Perfect, JR
Published in: Mycopathologia
1999

Cryptococcus neoformans is a basidiomycete that can cause life-threatening meningoencephalitis in patients with and without impaired immune function. Cryptococcosis is usually an opportunistic infection in patients with compromised immunity as a consequence of HIV-1 infection, steroid administration, cancer chemotherapy, sarcoidosis, diabetes, or inherited immune system defects. This pathogenic yeast has a defined sexual cycle, which allows classical genetic analysis. Molecular biology approaches, including transformation and gene disruption by homologous recombination, and animal models for studies of virulence are both well developed. Recently an international consortium convened to begin the C. neoformans genome sequencing project, and we review here background and arguments for this project. We also discuss the importance of this project to the biology and virulence of this organism in particular, and to virulence in general.

Duke Scholars

Published In

Mycopathologia

DOI

ISSN

0301-486X

Publication Date

1999

Volume

148

Issue

1

Start / End Page

1 / 7

Location

Netherlands

Related Subject Headings

  • Virulence
  • Sequence Analysis, DNA
  • Microbiology
  • Humans
  • Genome, Fungal
  • Cryptococcus neoformans
  • Cryptococcosis
  • Antifungal Agents
  • AIDS-Related Opportunistic Infections
  • 3107 Microbiology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Heitman, J., Casadevall, A., Lodge, J. K., & Perfect, J. R. (1999). The Cryptococcus neoformans genome sequencing project. Mycopathologia, 148(1), 1–7. https://doi.org/10.1023/a:1007136602930
Heitman, J., A. Casadevall, J. K. Lodge, and J. R. Perfect. “The Cryptococcus neoformans genome sequencing project.Mycopathologia 148, no. 1 (1999): 1–7. https://doi.org/10.1023/a:1007136602930.
Heitman J, Casadevall A, Lodge JK, Perfect JR. The Cryptococcus neoformans genome sequencing project. Mycopathologia. 1999;148(1):1–7.
Heitman, J., et al. “The Cryptococcus neoformans genome sequencing project.Mycopathologia, vol. 148, no. 1, 1999, pp. 1–7. Pubmed, doi:10.1023/a:1007136602930.
Heitman J, Casadevall A, Lodge JK, Perfect JR. The Cryptococcus neoformans genome sequencing project. Mycopathologia. 1999;148(1):1–7.
Journal cover image

Published In

Mycopathologia

DOI

ISSN

0301-486X

Publication Date

1999

Volume

148

Issue

1

Start / End Page

1 / 7

Location

Netherlands

Related Subject Headings

  • Virulence
  • Sequence Analysis, DNA
  • Microbiology
  • Humans
  • Genome, Fungal
  • Cryptococcus neoformans
  • Cryptococcosis
  • Antifungal Agents
  • AIDS-Related Opportunistic Infections
  • 3107 Microbiology