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Signal transduction cascades regulating fungal development and virulence.

Publication ,  Journal Article
Lengeler, KB; Davidson, RC; D'souza, C; Harashima, T; Shen, WC; Wang, P; Pan, X; Waugh, M; Heitman, J
Published in: Microbiol Mol Biol Rev
December 2000

Cellular differentiation, mating, and filamentous growth are regulated in many fungi by environmental and nutritional signals. For example, in response to nitrogen limitation, diploid cells of the yeast Saccharomyces cerevisiae undergo a dimorphic transition to filamentous growth referred to as pseudohyphal differentiation. Yeast filamentous growth is regulated, in part, by two conserved signal transduction cascades: a mitogen-activated protein kinase cascade and a G-protein regulated cyclic AMP signaling pathway. Related signaling cascades play an analogous role in regulating mating and virulence in the plant fungal pathogen Ustilago maydis and the human fungal pathogens Cryptococcus neoformans and Candida albicans. We review here studies on the signaling cascades that regulate development of these and other fungi. This analysis illustrates both how the model yeast S. cerevisiae can serve as a paradigm for signaling in other organisms and also how studies in other fungi provide insights into conserved signaling pathways that operate in many divergent organisms.

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Published In

Microbiol Mol Biol Rev

DOI

ISSN

1092-2172

Publication Date

December 2000

Volume

64

Issue

4

Start / End Page

746 / 785

Location

United States

Related Subject Headings

  • Transcription Factors
  • Receptor Cross-Talk
  • Pheromones
  • Microbiology
  • MAP Kinase Signaling System
  • GTP-Binding Proteins
  • Fungi
  • Cyclic AMP-Dependent Protein Kinases
  • Cyclic AMP
  • Calcineurin
 

Citation

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Lengeler, K. B., Davidson, R. C., D’souza, C., Harashima, T., Shen, W. C., Wang, P., … Heitman, J. (2000). Signal transduction cascades regulating fungal development and virulence. Microbiol Mol Biol Rev, 64(4), 746–785. https://doi.org/10.1128/MMBR.64.4.746-785.2000
Lengeler, K. B., R. C. Davidson, C. D’souza, T. Harashima, W. C. Shen, P. Wang, X. Pan, M. Waugh, and J. Heitman. “Signal transduction cascades regulating fungal development and virulence.Microbiol Mol Biol Rev 64, no. 4 (December 2000): 746–85. https://doi.org/10.1128/MMBR.64.4.746-785.2000.
Lengeler KB, Davidson RC, D’souza C, Harashima T, Shen WC, Wang P, et al. Signal transduction cascades regulating fungal development and virulence. Microbiol Mol Biol Rev. 2000 Dec;64(4):746–85.
Lengeler, K. B., et al. “Signal transduction cascades regulating fungal development and virulence.Microbiol Mol Biol Rev, vol. 64, no. 4, Dec. 2000, pp. 746–85. Pubmed, doi:10.1128/MMBR.64.4.746-785.2000.
Lengeler KB, Davidson RC, D’souza C, Harashima T, Shen WC, Wang P, Pan X, Waugh M, Heitman J. Signal transduction cascades regulating fungal development and virulence. Microbiol Mol Biol Rev. 2000 Dec;64(4):746–785.

Published In

Microbiol Mol Biol Rev

DOI

ISSN

1092-2172

Publication Date

December 2000

Volume

64

Issue

4

Start / End Page

746 / 785

Location

United States

Related Subject Headings

  • Transcription Factors
  • Receptor Cross-Talk
  • Pheromones
  • Microbiology
  • MAP Kinase Signaling System
  • GTP-Binding Proteins
  • Fungi
  • Cyclic AMP-Dependent Protein Kinases
  • Cyclic AMP
  • Calcineurin