Signal-transduction cascades as targets for therapeutic intervention by natural products.
Journal Article (Journal Article;Review)
Many bacteria and fungi produce natural products that are toxic to other microorganisms and have a variety of physiological effects in animals. Recent studies have revealed that, in several cases, the targets of these agents are components of conserved signal-transduction cascades. This article looks at the mechanisms of action of five natural products--the immunosuppressants cyclosporin A, FK506 and rapamycin, and the antiproliferative agents wortmannin and geldanamycin. These mechanisms reveal the importance of signal-transduction cascades as targets for therapeutic intervention and the enormous utility of studies of natural-product action in simple model genetic systems.
Full Text
Duke Authors
Cited Authors
- Cardenas, ME; Sanfridson, A; Cutler, NS; Heitman, J
Published Date
- October 1998
Published In
Volume / Issue
- 16 / 10
Start / End Page
- 427 - 433
PubMed ID
- 9807840
International Standard Serial Number (ISSN)
- 0167-7799
Digital Object Identifier (DOI)
- 10.1016/s0167-7799(98)01239-6
Language
- eng
Conference Location
- England