Comparison of the roles of calcineurin in physiology and virulence in serotype D and serotype A strains of Cryptococcus neoformans.
Journal Article
The calcineurin gene was cloned and disrupted in serotype D strains of Cryptococcus neoformans. Serotype A and serotype D calcineurin mutants were inviable at 37 degrees C and avirulent in mice, whereas only serotype A mutants were cation stress sensitive. Thus, calcineurin plays conserved and divergent roles in serotype A and serotype D strains.
Full Text
Duke Authors
Cited Authors
- Cruz, MC; Sia, RA; Olson, M; Cox, GM; Heitman, J
Published Date
- February 2000
Published In
Volume / Issue
- 68 / 2
Start / End Page
- 982 - 985
PubMed ID
- 10639477
Pubmed Central ID
- 10639477
International Standard Serial Number (ISSN)
- 0019-9567
Digital Object Identifier (DOI)
- 10.1128/iai.68.2.982-985.2000
Language
- eng
Conference Location
- United States