Comparison of the roles of calcineurin in physiology and virulence in serotype D and serotype A strains of Cryptococcus neoformans.

Journal Article (Journal Article)

The calcineurin gene was cloned and disrupted in serotype D strains of Cryptococcus neoformans. Serotype A and serotype D calcineurin mutants were inviable at 37 degrees C and avirulent in mice, whereas only serotype A mutants were cation stress sensitive. Thus, calcineurin plays conserved and divergent roles in serotype A and serotype D strains.

Full Text

Duke Authors

Cited Authors

  • Cruz, MC; Sia, RA; Olson, M; Cox, GM; Heitman, J

Published Date

  • February 2000

Published In

Volume / Issue

  • 68 / 2

Start / End Page

  • 982 - 985

PubMed ID

  • 10639477

Pubmed Central ID

  • PMC97236

International Standard Serial Number (ISSN)

  • 0019-9567

Digital Object Identifier (DOI)

  • 10.1128/IAI.68.2.982-985.2000


  • eng

Conference Location

  • United States