The TOR kinases link nutrient sensing to cell growth.

Journal Article (Review)

Rapamycin is an immunosuppressive natural product that inhibits the proliferation of T-cells in response to nutrients and growth factors. Rapamycin binds to the peptidyl-prolyl isomerase FKBP12 and forms protein-drug complexes that inhibit signal transduction by the TOR kinases. The FKBP12 and TOR proteins are conserved from fungi to humans, and in both organisms the TOR signaling pathway plays a role in nutrient sensing. In response to nitrogen sources or amino acids, TOR regulates both transcription and translation, enabling cells to appropriately respond to growth-promoting signals. Rapamycin is having a profound impact on clinical medicine and was approved as an immunosuppressant for transplant recipients in 1999. Ongoing clinical studies address new clinical applications for rapamycin as an antiproliferative drug for chemotherapy and invasive cardiology.

Full Text

Duke Authors

Cited Authors

  • Rohde, J; Heitman, J; Cardenas, ME

Published Date

  • March 30, 2001

Published In

Volume / Issue

  • 276 / 13

Start / End Page

  • 9583 - 9586

PubMed ID

  • 11266435

International Standard Serial Number (ISSN)

  • 0021-9258

Digital Object Identifier (DOI)

  • 10.1074/jbc.R000034200

Language

  • eng

Conference Location

  • United States