Sp1 transcription factor is required for in vitro basal and Tat-activated transcription from the human immunodeficiency virus type 1 long terminal repeat.

Journal Article

Sp1-DNA binding sites have been reported to be essential for basal and Tat-activated transcription of the human immunodeficiency virus type 1 long terminal repeat (LTR). The role of the Sp1 transcription factor itself in regulation of the retroviral LTR, however, has not been clearly defined. It is now known, for instance, that the Sp1-DNA binding sites function also as thyroid hormone receptor response elements (V. Desay-Yajnik and H. H. Samuels, Mol. Cell. Biol. 13:5057-5069, 1993). In this report, we present data that demonstrate a strict requirement for Sp1 for both basal transcription and Tat-mediated trans activation of the human immunodeficiency virus type 1 LTR in vitro.

Full Text

Duke Authors

Cited Authors

  • Suñé, C; García-Blanco, MA

Published Date

  • October 1995

Published In

Volume / Issue

  • 69 / 10

Start / End Page

  • 6572 - 6576

PubMed ID

  • 7666561

International Standard Serial Number (ISSN)

  • 0022-538X

Language

  • eng

Conference Location

  • United States