Effect of human gamma interferon on yellow fever virus infection.

Journal Article (Journal Article)

We studied yellow fever virus infection in two species of monkey: Saimiri sciureus (squirrel monkeys) and Macaca mulatta (rhesus monkeys). Human gamma interferon was administered intravenously in five equal doses, one was given 24 hr before infection followed by four doses 24 hr apart. Interferon reduced the levels and duration of viremia and the severity of hepatitis in squirrel monkeys. Interferon prolonged survival time and delayed the appearance of viremia and hepatitis in infected rhesus monkeys, but it did not change overall mortality.

Full Text

Duke Authors

Cited Authors

  • Arroyo, JI; Apperson, SA; Cropp, CB; Marafino, BJ; Monath, TP; Tesh, RB; Shope, RE; Garcia-Blanco, MA

Published Date

  • May 1988

Published In

Volume / Issue

  • 38 / 3

Start / End Page

  • 647 - 650

PubMed ID

  • 3152785

International Standard Serial Number (ISSN)

  • 0002-9637


  • eng

Conference Location

  • United States