A functional genetic approach suggests a novel interaction between the human immunodeficiency virus type 1 (HIV-1) Tat protein and HIV-1 TAR RNA in vivo.

Journal Article

Human immunodeficiency virus type 1 (HIV-1) Tat and human Cyclin T1 form a complex and together recognize the viral TAR RNA element with specificity. Using HIV-1/equine infectious anaemia virus TAR chimeras, we show that in addition to the well-characterized interaction with the bulge, Tat recognizes the distal stem and the loop of TAR. These data support previously proposed, but unproven, molecular models.

Full Text

Duke Authors

Cited Authors

  • Lund, LH; Wahren, B; Garcia-Blanco, MA

Published Date

  • March 2003

Published In

Volume / Issue

  • 84 / Pt 3

Start / End Page

  • 603 - 606

PubMed ID

  • 12604811

International Standard Serial Number (ISSN)

  • 0022-1317

Digital Object Identifier (DOI)

  • 10.1099/vir.0.18645-0

Language

  • eng

Conference Location

  • England