Messenger RNA reprogramming by spliceosome-mediated RNA trans-splicing.

Journal Article (Review)

In the human genome, the majority of protein-encoding genes are interrupted by introns, which are removed from primary transcripts by a macromolecular enzyme known as the spliceosome. Spliceosomes can constitutively remove all the introns in a primary transcript to yield a fully spliced mRNA or alternatively splice primary transcripts leading to the production of many different mRNAs from one gene. This review examines how spliceosomes can recombine two primary transcripts in trans to reprogram messenger RNAs.

Full Text

Duke Authors

Cited Authors

  • Garcia-Blanco, MA

Published Date

  • August 2003

Published In

Volume / Issue

  • 112 / 4

Start / End Page

  • 474 - 480

PubMed ID

  • 12925685

International Standard Serial Number (ISSN)

  • 0021-9738

Digital Object Identifier (DOI)

  • 10.1172/JCI19462

Language

  • eng

Conference Location

  • United States