Messenger RNA reprogramming by spliceosome-mediated RNA trans-splicing.
Journal Article (Journal Article;Review)
In the human genome, the majority of protein-encoding genes are interrupted by introns, which are removed from primary transcripts by a macromolecular enzyme known as the spliceosome. Spliceosomes can constitutively remove all the introns in a primary transcript to yield a fully spliced mRNA or alternatively splice primary transcripts leading to the production of many different mRNAs from one gene. This review examines how spliceosomes can recombine two primary transcripts in trans to reprogram messenger RNAs.
Full Text
Duke Authors
Cited Authors
- Garcia-Blanco, MA
Published Date
- August 2003
Published In
Volume / Issue
- 112 / 4
Start / End Page
- 474 - 480
PubMed ID
- 12925685
Pubmed Central ID
- PMC171395
International Standard Serial Number (ISSN)
- 0021-9738
Digital Object Identifier (DOI)
- 10.1172/JCI19462
Language
- eng
Conference Location
- United States