Skip to main content
Journal cover image

Mouse strain differences in the chemokine response to acute lung infection with a murine gammaherpesvirus.

Publication ,  Journal Article
Weinberg, JB; Lutzke, ML; Alfinito, R; Rochford, R
Published in: Viral Immunol
2004

Numerous mouse strain-based differences in the immune response and in susceptibility to numerous pathogens have been described, but it is not known if these differences extend to chemokine responses to viral infection of the lungs. To define mouse strain-based differences in the host chemokine response and susceptibility to infection with murine gammaherpesvirus-68 (MHV-68), we compared the induced chemokine response to MHV-68 infection in the lungs of BALB/c and C57BL/6 mice at 1-15 days post-infection. CC and CXC chemokines were induced in both BALB/c and C57BL/6 following infection but the level of chemokine induction was significantly higher in the BALB/c mice for all chemokines measured. In addition, interferon-gamma (IFN-gamma) was also induced to a significantly higher level in the lungs of BALB/c infected mice compared to C57BL/6 mice. Interestingly, viral gene expression was lower in the lungs of C57BL/6 mice during the acute phase of replication. Titers of infectious virus were also greater in BALB/c lungs, although they did not achieve statistical significance. In contrast, latent viral load in the spleen, as measured by quantitative real-time PCR, did not significantly differ between mouse strains, suggesting that the establishment of latency is not affected by the amount of virus present during acute infection. This data suggests that robust chemokine response and expression of IFN-gamma in the lungs of infected BALB/c mice does not correlate with increased resistance to infection. In addition, the significant differences in chemokine responses observed will be important factors to consider in future studies of viral pathogenesis using mouse models.

Duke Scholars

Published In

Viral Immunol

DOI

ISSN

0882-8245

Publication Date

2004

Volume

17

Issue

1

Start / End Page

69 / 77

Location

United States

Related Subject Headings

  • Virus Replication
  • Virus Latency
  • Virology
  • Viral Proteins
  • Viral Load
  • Species Specificity
  • Respiratory Tract Infections
  • Mice, Inbred C57BL
  • Mice, Inbred BALB C
  • Mice
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Weinberg, J. B., Lutzke, M. L., Alfinito, R., & Rochford, R. (2004). Mouse strain differences in the chemokine response to acute lung infection with a murine gammaherpesvirus. Viral Immunol, 17(1), 69–77. https://doi.org/10.1089/088282404322875467
Weinberg, Jason B., Mary L. Lutzke, Rosiane Alfinito, and Rosemary Rochford. “Mouse strain differences in the chemokine response to acute lung infection with a murine gammaherpesvirus.Viral Immunol 17, no. 1 (2004): 69–77. https://doi.org/10.1089/088282404322875467.
Weinberg JB, Lutzke ML, Alfinito R, Rochford R. Mouse strain differences in the chemokine response to acute lung infection with a murine gammaherpesvirus. Viral Immunol. 2004;17(1):69–77.
Weinberg, Jason B., et al. “Mouse strain differences in the chemokine response to acute lung infection with a murine gammaherpesvirus.Viral Immunol, vol. 17, no. 1, 2004, pp. 69–77. Pubmed, doi:10.1089/088282404322875467.
Weinberg JB, Lutzke ML, Alfinito R, Rochford R. Mouse strain differences in the chemokine response to acute lung infection with a murine gammaherpesvirus. Viral Immunol. 2004;17(1):69–77.
Journal cover image

Published In

Viral Immunol

DOI

ISSN

0882-8245

Publication Date

2004

Volume

17

Issue

1

Start / End Page

69 / 77

Location

United States

Related Subject Headings

  • Virus Replication
  • Virus Latency
  • Virology
  • Viral Proteins
  • Viral Load
  • Species Specificity
  • Respiratory Tract Infections
  • Mice, Inbred C57BL
  • Mice, Inbred BALB C
  • Mice