Underlying complement deficiency in patients with disseminated gonococcal infection.

Journal Article

The complement system was evaluated in 22 individuals with disseminated gonococcal infection. Three of the 22 patients exhibited a total serum complement activity that was greater than 2 SD below the normal mean. Of these three, one had a complete deficiency of C1r, a second patient had pre-existing systemic lupus erythematosus with low levels of C4, and the third had a C8 concentration that was 60% of normal. We conclude that the prevalence of inherited or acquired complement deficiency among patients with disseminated gonococcal infection exceeds that among the general population and is an important host factor predisposing to systemic infection with Neisseria gonorrhoeae.

Full Text

Duke Authors

Cited Authors

  • Ellison, RT; Curd, JG; Kohler, PF; Reller, LB; Judson, FN

Published Date

  • October 1, 1987

Published In

Volume / Issue

  • 14 / 4

Start / End Page

  • 201 - 204

PubMed ID

  • 2830678

International Standard Serial Number (ISSN)

  • 0148-5717

Language

  • eng

Conference Location

  • United States